A concise summary of the current evidence base for IV ketamine in treatment-resistant depression and related conditions, for primary care and behavioral-health colleagues considering referral. For patients with treatment-resistant depression (TRD) — roughly a third of the depressed population — rapid-acting glutamatergic agents have reshaped the treatment landscape. This brief summarizes what the recent literature says about subanesthetic IV ketamine, so you can counsel patie

Why what you do in the days after a ketamine infusion may matter as much as the infusion itself. There's a moment, sometime in the hours after a ketamine infusion, when the clinical language falls away and a simpler truth settles in: something has shifted. Patients describe it differently — a loosening, an opening, a sense that the mental grooves they've been stuck in aren't quite as deep as they were yesterday. That feeling isn't just subjective. It reflects something measur